Clustering Membrane Proteins: It's All Coming Together with the PSD-95/SAP90 Protein Family
نویسنده
چکیده
and b2-syntrophin, the DGC may localize the nAChR Neurons differentially localize and cluster membrane clusters to the synapse. proteins. Spatial localization and clustering of ion chanThe DGC also appears to localize signal transduction nels and neurotransmitter receptors are necessary for machinery. Neuronal-type nitric oxide synthase (nNOS) neurons to fire and propagate action potentials and for associates with the DGC and is concentrated at the normal synaptic transmission to occur. For example, sarcolemma of fast twitch skeletal muscle fibers (Brenvoltage-dependent sodium and potassium channels man et al., 1995). Many of the muscular dystrophies, must aggregate at the nodes of Ranvier of myelinated which cause progressive muscle weakness and premaaxons for action potentials to propagate. To accommo-
منابع مشابه
An intramolecular interaction between Src homology 3 domain and guanylate kinase-like domain required for channel clustering by postsynaptic density-95/SAP90.
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The molecular mechanisms underlying the organization of ion channels and signaling molecules at the synaptic junction are largely unknown. Recently, members of the PSD-95/SAP90 family of synaptic MAGUK (membrane-associated guanylate kinase) proteins have been shown to interact, via their NH2-terminal PDZ domains, with certain ion channels (NMDA receptors and K+ channels), thereby promoting the ...
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Postsynaptic density (PSD)-95/Synapse-associated protein (SAP) 90 and synaptic scaffolding molecule (S-SCAM) are neuronal membrane-associated guanylate kinases. Because PSD-95/SAP90 and S-SCAM function as synaptic scaffolding proteins, identification of ligands for these proteins is important to elucidate the structure of synaptic junctions. Here, we report a novel protein interacting with the ...
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عنوان ژورنال:
- Cell
دوره 84 شماره
صفحات -
تاریخ انتشار 1996